Search results for " IL-1β −511"

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Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis.

2008

Abstract The pro-inflammatory cytokine interleukin(IL)-1β is a main component in inflammatory pathways and is overexpressed in the brain of Alzheimer's disease (AD) patients. Several studies report associations between IL-1β polymorphisms and AD, but findings from different studies are controversial. Our aim was to verify the correlation between the single nucleotide polymorphisms (SNPs) of the IL-1β, at sites − 511 and + 3953, and AD by meta-analysis. Computerized bibliographic searches of PUBMED and AlzGene database ( http://www.alzgene.org ) were supplemented with manual searches of reference lists. There is evidence for association between IL-1β + 3953 SNP and AD, with an OR = 1.60 (95%…

OncologyDatabases Factual statistics /&/ numerical datamedicine.medical_specialtyDatabases FactualAlzheimer's disease IL-1β −511 IL-1β +3953 Polymorphism Meta-analysisPopulationInterleukin-1betaSingle-nucleotide polymorphismSubgroup analysisAlzheimer Disease geneticsMeta-Analysis as TopicPolymorphism (computer science)Alzheimer DiseaseInternal medicineGenotypemedicineSNPHumanseducationSettore MED/04 - Patologia Generaleeducation.field_of_studyPolymorphism Geneticbusiness.industryGeneral NeuroscienceComputational Biologymedicine.diseaseMeta-analysisImmunologyNeurology (clinical)Alzheimer's diseasebusinessInterleukin-1beta genetics

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